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应用微波辐射合成14-Helicalβ-Peptides(Application of Micro

 发布时间:2008-12-11 点击量:987

Abstract:

We have evaluated the effects of microwave irradiation on the solid-phase synthesis of B-peptides. Sequences designed to adopt the 14-helix, especially those containing the structure – promoting residue trans-2-aminocyclohexanecarboxylix acid (ACHC), suffer from poor synthetic efficiency under standard SPPS conditions. A comparision of microwaveconventional heating shows that both provide excellent synthetic results for shorter sequences; however, we identify a clear benefit from microwave irradiation for longer B-peptides.

应用微波辐射合成14-Helicalβ-Peptides


摘要:

    我们已经评估微波辐射对固相合成B-peptides的影响。在标准SPPS条件下, 序列用作吸纳14-螺旋(14-Helix)是存在非常低的合成效率,尤其是那些含有trans-2-aminocyclohexanecarboxylix acid (ACHC) 残余物的结构。比较微波加热和常规加热表明,两者都能为合成短序列多肽提供的综合成果;但是,我们确定微波辐射也能够为合成较长的乙肽(β-Peptides) 提供的综合成果。微波合成

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