产品搜索
产品目录
技术文章首页 > 技术文章 > CEM微波合成用于ACP 65 的合成
CEM微波合成用于ACP 65 的合成
点击次数:811 发布时间:2012-06-28

INTRODUCTION
The application of microwave energy has proved to be a major enabling tool for many chemical reactions requiring energy input, and recently microwave irradiation has been applied to solid phase peptide synthesis. Peptide synthesis often suffers from long reaction times and low yields due to problems such as aggregation. Microwave energy can help break up these aggregates improving the synthesis quality while speeding up the synthesis rate. The acyl carrier protein (ACP) fragment 65‐74,  H‐Val‐Gln‐Ala‐Ala‐Ile‐Asp‐Tyr‐Ile‐Asn‐Gly‐OH, is a widely used standard model for demonstrating peptide synthesis efficiency. The presence of several hydrophobic residues, and in particular the hindered Val and Ile residues, can lead to poor coupling and deprotection reactions resulting in low yield and purity of the peptide.

In this application note ACP 65‐74 is synthesized in good yield and purity using microwave irradiation for the deprotection, coupling, and final cleavage steps.

 

 
 Liberty 全自动流动微波多肽合成系统

 


更多详情,请培安公司:
:北京: 上海:  成都: 广州:
: sales@pynnco.com  www.pynnco.com
 

在线客服

化工仪器网

推荐收藏该企业网站