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技术文章首页 > 技术文章 > CEM微波合成用于γ-Lactam的研究
CEM微波合成用于γ-Lactam的研究
点击次数:1036 发布时间:2012-06-29

INTRODUCTION

One challenge facing peptide synthesis is the -lactam formation of arginine (Figure 1). The formation of -lactam occurs when the internal nitrogen of the guanidine attacks the activated ester, irreversibly forming the lactam ring. This reaction is competitive with peptide-bond formation, greatly reducing the coupling efficiency of arginine.

Figure 1: γ-Lactam Formation

The goal of this study was to determine what effect microwave irradiation has on -lactam formation and how to optimize the microwave synthesis of arginine-containing peptides. As a test substrate, we selected the 1992 ABRF study peptide sequence. This sequence is known to suffer from Arg deletion due to -lactam formation.

 
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